| Year | Title | Role | Notes | |
|---|---|---|---|---|
| 1981 | Endless Love | Billy | Cameo | |
| Taps | David Shawn | |||
| 1983 | The Outsiders | Steve Randle | ||
| Losin’ It | Woody | |||
| Risky Business | Joel Goodson | |||
| All the Right Moves | Stefan Djordjevic | |||
| 1985 | Legend | Jack | ||
| 1986 | Top Gun | Lieutenant Pete “Maverick” Mitchell | ||
| The Color of Money | Vincent Lauria | |||
| 1988 | Cocktail | Brian Flanagan | ||
| Rain Man | Charlie Babbitt | |||
| 1989 | Born on the Fourth of July | Ron Kovic | ||
| 1990 | Days of Thunder | Cole Trickle | Also co-wrote story | |
| 1992 | Far and Away | Joseph Donelly | ||
| A Few Good Men | Lieutenant Daniel Kaffee | |||
| 1993 | The Firm | Mitch McDeere | ||
| 1994 | Interview with the Vampire | Lestat de Lioncourt | ||
| 1996 | Mission: Impossible | Ethan Hunt | Also producer | |
| Jerry Maguire | Jerry Maguire | |||
| 1998 | Without Limits | N/A | Producer only | |
| 1999 | Eyes Wide Shut | Bill Harford | ||
| Magnolia | Frank T.J. Mackey | |||
| 2000 | Mission: Impossible 2 | Ethan Hunt | Also producer | |
| 2001 | Stanley Kubrick: A Life in Pictures | Himself / Narrator | ||
| The Others | N/A | Executive producer only | ||
| Vanilla Sky | David Aames | Also producer | ||
| 2002 | Space Station 3D | Narrator | ||
| Minority Report | John Anderton | |||
| Austin Powers in Goldmember | Himself as Austin Powers | Cameo uncredited | ||
| Narc | N/A | Executive producer only | ||
| 2003 | Shattered Glass | N/A | Executive producer only | |
| The Last Samurai | Nathan Algren | Also producer | ||
| 2004 | Collateral | Vincent | ||
| 2005 | War of the Worlds | Ray Ferrier | ||
| Elizabethtown | N/A | Producer only | ||
| 2006 | Ask the Dust | N/A | Producer only | |
| Mission: Impossible III | Ethan Hunt | Also producer | ||
| 2007 | Lions for Lambs | Senator Jasper Irving | ||
| 2008 | Tropic Thunder | Les Grossman | ||
| Valkyrie | Claus von Stauffenberg | |||
| 2010 | Knight and Day | Roy Miller/Matthew Knight | ||
| 2011 | Mission: Impossible – Ghost Protocol | Ethan Hunt | Also producer | |
| 2012 | Rock of Ages | Stacee Jaxx | Also credited as singer on the film’s soundtrack | |
| Jack Reacher | Jack Reacher | Also producer | ||
| 2013 | Oblivion | Jack Harper | ||
| 2014 | Edge of Tomorrow | Major William Cage | ||
| 2015 | Mission: Impossible – Rogue Nation | Ethan Hunt | Also producer | |
| 2016 | Jack Reacher: Never Go Back | Jack Reacher | Also producer | |
| 2017 | The Mummy | Nick Morton | ||
| American Made | Barry Seal | |||
| 2018 | Mission: Impossible – Fallout | Ethan Hunt | Also producer | |
| 2022 | Top Gun: Maverick | Captain Pete “Maverick” Mitchell | Also producer | |
| 2023 | Mission: Impossible – Dead Reckoning Part One  |
Ethan Hunt | Also producer; post-production | |
| 2024 | Mission: Impossible – Dead Reckoning Part Two |
Also producer; filming |
